The Science
Behind

Superior Beta MD™ Complete Relief is a novel composition developed to deeply moisturize and nourish the skin while aiding in the relief of pain, inflammation, aging, scarring as well as reduce susceptibility to contact from pathogens and insects. The natural pain relieving, antiseptic and anti-inflammatory ingredients are carefully formulated to soothe and refresh. 

Beta-caryophyllene (BCP) is a key ingredient found in our formulation at concentrations much higher than those found in many commercially available creams. Our Beta-Caryophyllene is steam distilled from clove buds and is Generally Regarded As Safe by the FDA (GRAS). Our products are formulated with ingredients used for centuries. Superior Beta MD™ has developed a unique formula to retain the biological activity of each ingredient while simultaneously maintaining stability and product safety.  Many of the known activities of Beta-Caryophyllene are attributed to its activity at the Cannabinoid type 2 receptor and include:

  • Analgesic properties [1-6]

  • Calming effects [6, 7]
     

  • Anti-inflammatory [8-11]
     

  • Antibacterial and antifungal [9, 12, 13]

Organic and fair trade shea and mango butters are derived from shea nuts and mango pits

that have been used for thousands of years for their powerful moisturizing properties.

In Superior Beta MD™ Complete Relief, these plants derived butters sooth, moisturize and protect the skin.

Lecithin is rich source of phospholipids and carry our active ingredients through the skin. Because it contains phosphatidylcholines, lecithin is a source of choline, an essential nutrient that has demonstrated activity against acne.[14]

Essential oils of tea tree and lemon grass have been recognized for centuries by aboriginal

peoples for their healing properties, and strong antimicrobial actions. In Superior Beta MD™ Complete Relief they provide soothing relief and a fresh scent.[14-16]

Conditions that may benefit from our products include:

  • Arthritic or overuse inflammation
     

  • Joint pain
     

  • Post-operative healing
     

  • Sore muscles
     

  • Neuropathic pain
     

  • Rosacea
     

  • Insect bites
     

  • Poison oak and ivy
     

  • Fine lines and wrinkles
     

  • Dry skin
     

  • Age Spots

References

1. Fidyt K, Fiedorowicz A, Strzadala L, Szumny A: beta-caryophyllene and beta-caryophyllene oxide-natural compounds of anticancer and analgesic properties. Cancer Med 5:3007, 2016

2. Fiorenzani P, Lamponi S, Magnani A, Ceccarelli I, Aloisi AM: In vitro and in vivo characterization of the new analgesic combination Beta-caryophyllene and docosahexaenoic Acid. Evid Based Complement Alternat Med 2014:596312, 2014

3. Ghelardini C, Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A: Local anaesthetic activity of beta-caryophyllene. Farmaco 56:387, 2001

4. Katsuyama S, Mizoguchi H, Kuwahata H, Komatsu T, Nagaoka K, Nakamura H, Bagetta G, Sakurada T, Sakurada S: Involvement of peripheral cannabinoid and opioid receptors in beta-caryophyllene-induced antinociception. Eur J Pain 17:664, 2013

5. Klauke AL, Racz I, Pradier B, Markert A, Zimmer AM, Gertsch J, Zimmer A: The cannabinoid CB(2) receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. Eur Neuropsychopharmacol 24:608, 2014

6. Sharma C, Al Kaabi JM, Nurulain SM, Goyal SN, Kamal MA, Ojha S: Polypharmacological Properties and Therapeutic Potential of beta-Caryophyllene: A Dietary Phytocannabinoid of Pharmaceutical Promise. Curr Pharm Des 22:3237, 2016

7. Bahi A, Al Mansouri S, Al Memari E, Al Ameri M, Nurulain SM, Ojha S: beta-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice. Physiol Behav 135:119, 2014

8. Chang HJ, Kim JM, Lee JC, Kim WK, Chun HS: Protective effect of beta-caryophyllene, a natural bicyclic sesquiterpene, against cerebral ischemic injury. J Med Food 16:471, 2013

9. Dahham SS, Tabana YM, Iqbal MA, Ahamed MB, Ezzat MO, Majid AS, Majid AM: The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene beta-Caryophyllene from the Essential Oil of Aquilaria crassna. Molecules 20:11808, 2015

10. Ojha S, Javed H, Azimullah S, Haque ME: beta-Caryophyllene, a phytocannabinoid attenuates oxidative stress, neuroinflammation, glial activation, and salvages dopaminergic neurons in a rat model of Parkinson disease. Mol Cell Biochem 418:59, 2016

11. Pant A, Saikia SK, Shukla V, Asthana J, Akhoon BA, Pandey R: Beta-caryophyllene modulates expression of stress response genes and mediates longevity in Caenorhabditis elegans. Exp Gerontol 57:81, 2014

12. Govindarajan M, Rajeswary M, Hoti SL, Bhattacharyya A, Benelli G: Eugenol, alpha-pinene and beta-caryophyllene from Plectranthus barbatus essential oil as eco-friendly larvicides against malaria, dengue and Japanese encephalitis mosquito vectors. Parasitol Res 115:807, 2016

13. Pieri FA, Souza MC, Vermelho LL, Vermelho ML, Perciano PG, Vargas FS, Borges AP, da Veiga-Junior VF, Moreira MA: Use of beta-caryophyllene to combat bacterial dental plaque formation in dogs. BMC Vet Res 12:216, 2016

14. Ebadi M: Pharmacodynamic basis of herbal medicine. (ed. 2). Boca Raton, FL, CRC Press, Taylor and Frances Group, 2007

15. Boukhatem MN, Ferhat MA, Kameli A, Saidi F, Kebir HT: Lemon grass (Cymbopogon citratus) essential oil as a potent anti-inflammatory and antifungal drugs. Libyan J Med 9:25431, 2014

16. Rothenberger J, Krauss S, Tschumi C, Rahmanian-Schwarz A, Schaller HE, Held M: The Effect of Polyhexanide, Octenidine Dihydrochloride, and Tea Tree Oil as Topical Antiseptic Agents on In Vivo Microcirculation of the Human Skin: A Noninvasive Quantitative Analysis. Wounds 28:341, 2016

17. Caterina M, TRP Channel Cannabinoid Receptors in Skin Sensation, Homeostasis, and Inflammation, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240254/

18. Ständer S, Schmelz M, Metze D, Luger T, Rukwied R, Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin, http://www.jdsjournal.com/article/S0923-1811(05)00028-9/fulltext

19. Mounessa J,Siegel J, Dunnick C, Dellavalle R, The role of cannabinoids in dermatology, http://www.jaad.org/article/S0190-9622(17)30308-0/fulltext

20. https://www.ncbi.nlm.nih.gov/m/pubmed/

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P.O. Box 41496

Eugene, Oregon 97404

541-844-5005

FDA Disclosure:

*These statements have not been evaluated by the FDA and are not intended to diagnose, treat or cure any disease.

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